Comparing T- and B-cell responses to COVID-19 vaccines across varied immune backgrounds.

ABSTRACT: The emergence of adapted variants of the SARS-CoV-2 virus has led to a surge in breakthrough infections worldwide. A recent analysis of immune responses in people who received inactivated vaccines has revealed that individuals with no prior infection have limited resistance to Omicron and its sub-lineages, while those with previous infections exhibit a significant amount of neutralizing antibodies and memory B cells. However, specific T-cell responses remain largely unaffected by the mutations, indicating that T-cell-mediated cellular immunity can still provide protection. Moreover, the administration of a third dose of vaccine has resulted in a marked increase in the spectrum and duration of neutralizing antibodies and memory B cells in vivo, which has enhanced resistance to emerging vari

SUBMITTER: Cui Z 

PROVIDER: S-EPMC10157553 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature