CFOS expression in the prefrontal cortex correlates with altered cerebral metabolism in developing germ-free mice.

ABSTRACT:

Introduction

The microbiota plays a critical role in modulating various aspects of host physiology, particularly through the microbiota-gut-brain (MGB) axis. However, the mechanisms that transduce and affect gut-to-brain communication are still not well understood. Recent studies have demonstrated that dysbiosis of the microbiome is associated with anxiety and depressive symptoms, which are common complications of metabolic syndrome. Germ-free (GF) animal models offer a valuable tool for studying the causal effects of microbiota on the host.

Methods

We employed gene expression and nuclear magnetic resonance (NMR)-based metabolomic techniques to investigate the relationships between brain plasticity and immune gene expression, peripheral immunity, and cerebral and liver metab

SUBMITTER: Pate T 

PROVIDER: S-EPMC10157641 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature