Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity.

ABSTRACT: Selective serotonin reuptake inhibitors (SSRIs) increase serotonin activity in the brain. While they are mostly known for their antidepressant properties, they have been shown to improve visual functions in amblyopia and impact cognitive functions ranging from attention to motivation and sensitivity to reward. Yet, a clear understanding of the specific action of serotonin to each of bottom-up sensory and top-down cognitive control components and their interaction is still missing. To address this question, we characterize, in two adult male macaques, the behavioral effects of fluoxetine, a specific SSRI, on visual perception under varying bottom-up (luminosity, distractors) and top-down (uncertainty, reward biases) constraints while they are performing three different visual tasks. We firs

SUBMITTER: Gacoin M 

PROVIDER: S-EPMC10157648 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature