Microcontact-Imprinted Optical Sensors for Virulence Factors of Periodontal Disease.

ABSTRACT: Periodontitis (gum disease) is a common biofilm-mediated oral condition, with around 7% of the adult population suffering from severe disease with risk for tooth loss. Moreover, periodontitis virulence markers have been found in atherosclerotic plaque and brain tissue, suggesting a link to cardiovascular and Alzheimer's diseases. The lack of accurate, fast, and sensitive clinical methods to identify patients at risk leads, on the one hand, to patients being undiagnosed until the onset of severe disease and, on the other hand, to overtreatment of individuals with mild disease, diverting resources from those patients most in need. The periodontitis-associated bacterium, Porphyromonas gingivalis, secrete gingipains which are highly active proteases recognized as key virulence factors d

SUBMITTER: Hix-Janssens T 

PROVIDER: S-EPMC10157856 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature