Effective Synthesis and Biological Evaluation of Dicoumarols: Preparation, Characterization, and Docking Studies.

ABSTRACT: A series of 3,3-arylidene bis (4-hydroxycoumarins) 2 were synthesized by the reaction of aromatic aldehydes with 4-hydroxycoumarin using dodecylbenzenesulfonic acid as Brønsted acid-surfactant catalyst in aqueous media and under microwave irradiation. The present method is operationally simple and the use of water as the reaction medium makes the process environmentally benign. The epoxydicoumarins 5 were then obtained with a good yield by heating 3,3'-arylidenebis-4-hydroxycoumarins 2 in acetic anhydride. Techniques such as elemental analysis, ¹H, ¹³C-¹H NMR, and infrared spectroscopy were employed to characterize these compounds. The synthesized compounds displayed good antibacterial potential against Escherichia coli (ATCC 259

SUBMITTER: Mnasri A 

PROVIDER: S-EPMC10157871 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature