Efficacy of aluminum chloride in severe regorafenib-associated hand-foot skin reactions: a single-arm trial.

ABSTRACT:

Background

Regorafenib, a multikinase inhibitor, causes a high frequency of hand-foot skin reactions (HFSRs). The present study evaluated the efficacy of topical aluminum chloride, a perspiration suppressant, in reducing the severity of hand-foot skin reactions (HFSRs) caused by regorafenib.

Methods

The present single-arm study included patients with metastatic colorectal cancer receiving regorafenib. Aluminum chloride ointment was applied topically one week prior to the start of regorafenib treatment, and the observation period was 12 weeks. The primary endpoint was the incidence of regorafenib-related grade 3 HFSR. Secondary endpoints were the incidence of all grades of HFSR, time to any grade of HFSR, time to improvement from grade 2 or higher to grade 1 or lower, treatme

SUBMITTER: Nishizawa A 

PROVIDER: S-EPMC10157908 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature