Genome-wide assessment and mapping of inbreeding depression identifies candidate genes associated with semen traits in Holstein bulls.

ABSTRACT:

Background

The reduction in phenotypic performance of a population due to mating between close relatives is called inbreeding depression. The genetic background of inbreeding depression for semen traits is poorly understood. Thus, the objectives were to estimate the effect of inbreeding and to identify genomic regions underlying inbreeding depression of semen traits including ejaculate volume (EV), sperm concentration (SC), and sperm motility (SM). The dataset comprised ~ 330 K semen records from ~ 1.5 K Holstein bulls genotyped with 50 K single nucleotide polymorphism (SNP) BeadChip. Genomic inbreeding coefficients were estimated using runs of homozygosity (i.e., F_ROH > 1 Mb) and excess of SNP homozygosity (F_SNP). The effect of inbreeding was estimated by reg

SUBMITTER: Ghoreishifar M 

PROVIDER: S-EPMC10157977 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature