Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson's disease.

ABSTRACT:

Background

Non-motor symptoms are an important early feature of Parkinson's disease (PD), encompassing a variety of cognitive and psychiatric symptoms that seem to manifest differently depending on motor symptom asymmetry. Different factors, such as uric acid (UA) and sex, seem to influence cognitive and psychiatric expression in PD, however their interplay remains to be better understood.

Methods

Participants taking part in the Parkinson's Progression Marker Initiative were studied based on the side of motor symptom asymmetry and sex. Three-way interaction modeling was used to examine the moderating effects of sex and UA on cognitive functions and psychiatric symptoms.

Results

Significant three-way interactions were highlighted at 1-year follow-up between motor sympt

SUBMITTER: Constantin IM 

PROVIDER: S-EPMC10157998 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature