Integrative network fusion-based multi-omics study for biomarker identification and patient classification of rheumatoid arthritis.

ABSTRACT:

Background

Cold-dampness Syndrome (RA-Cold) and Hot-dampness Syndrome (RA-Hot) are two distinct groups of rheumatoid arthritis (RA) patients with different clinical symptoms based on traditional Chinese medicine (TCM) theories and clinical empirical knowledge. However, the biological basis of the two syndromes has not been fully elucidated, which may restrict the development of personalized medicine and drug discovery for RA diagnosis and therapy.

Methods

An integrative strategy combining clinical transcriptomics, phenomics, and metabolomics data based on clinical cohorts and adjuvant-induced arthritis rat models was performed to identify novel candidate biomarkers and to investigate the biological basis of RA-Cold and RA-Hot.

Results

The main clinical symptoms of RA-

SUBMITTER: Ding Z 

PROVIDER: S-EPMC10158004 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature