Telomere-to-Telomere genome assemblies of human-infecting Encephalitozoon species.

ABSTRACT:

Background

Microsporidia are diverse spore forming, fungal-related obligate intracellular pathogens infecting a wide range of hosts. This diversity is reflected at the genome level with sizes varying by an order of magnitude, ranging from less than 3 Mb in Encephalitozoon species (the smallest known in eukaryotes) to more than 50 Mb in Edhazardia spp. As a paradigm of genome reduction in eukaryotes, the small Encephalitozoon genomes have attracted much attention with investigations revealing gene dense, repeat- and intron-poor genomes characterized by a thorough pruning of molecular functions no longer relevant to their obligate intracellular lifestyle. However, because no Encephalitozoon genome has been sequenced from telomere-to-telomere and since no methylation data is available

SUBMITTER: Mascarenhas Dos Santos AC 

PROVIDER: S-EPMC10158259 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature