Incidence proportion and prognosis of leptomeningeal disease among patients with breast vs. non-breast primaries.

ABSTRACT:

Background

Leptomeningeal disease (LMD) is a relatively uncommon manifestation of advanced cancer. Patients with LMD carry a poor prognosis and often decline rapidly, complicating inclusion in clinical trials. Identification of LMD subsets of greater incidence and more favorable prognosis might facilitate dedicated clinical trials in the future. We hypothesized that patients with breast cancer may represent such a population and sought to assess the relative incidence and prognosis of LMD secondary to breast vs. non-breast primaries.

Methods

We identified 2411 patients with intracranial metastases secondary to breast (N = 501) and non-breast (N = 1910) primaries at Brigham and Women's Hospital/Dana-Farber Cancer Institute between 1996 and 2020, of whom 112 presented with and

SUBMITTER: Lamba N 

PROVIDER: S-EPMC10158280 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature