Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group.

ABSTRACT:

Background

Terminology to describe extent of resection in glioblastoma is inconsistent across clinical trials. A surgical classification system was previously proposed based upon residual contrast-enhancing (CE) tumor. We aimed to (1) explore the prognostic utility of the classification system and (2) define how much removed non-CE tumor translates into a survival benefit.

Methods

The international RANO resect group retrospectively searched previously compiled databases from 7 neuro-oncological centers in the USA and Europe for patients with newly diagnosed glioblastoma per WHO 2021 classification. Clinical and volumetric information from pre- and postoperative MRI were collected.

Results

We collected 1,008 patients with newly diagnosed IDHwt glioblastoma. 744 IDHwt g

SUBMITTER: Karschnia P 

PROVIDER: S-EPMC10158281 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature