Temporal interference current stimulation in peripheral nerves is not driven by envelope extraction.

ABSTRACT: Background. Electrical neuromodulation remains an effective therapy for multiple neurological disorders. One strategy to electrically stimulate nerves utilizes the interference of multiple high frequency waveforms. This technique, known as temporal interference stimulation or interferential current stimulation, has recently gained significant attention as a method to improve the state-of-the-art in neurostimulation in both animal studies and human clinical trials.Objective.Here we report our investigation into the fundamental properties of the neuronal response to these types of waveforms-the effects of carrier and envelope frequencies, thresholds, firing behavior, and phase and asymmetric interference patterns.Methods.We utilized a cuff electrode on the rat sciatic ne

SUBMITTER: Budde RB 

PROVIDER: S-EPMC10158317 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature