Phosphofructokinase Platelet Overexpression Accelerated Colorectal Cancer Cell Growth and Motility.

ABSTRACT: Background: Glycolysis is a glucose metabolism pathway that generates the high-energy compound adenosine triphosphate, which supports cancer cell growth. Phosphofructokinase platelet (PFKP) plays a crucial role in glycolysis regulation and is involved in human cancer progression. However, the biological function of PFKP remains unclear in colorectal cancer (CRC). Methods: We analyzed the expression levels of PFKF in colon cancer cells and clinical samples using real-time PCR and western blot techniques. To determine the clinical significance of PFKP expression in colorectal cancer (CRC), we analyzed public databases. In addition, we conducted in vitro assays to investigate the effects of PFKP on cell growth, cell cycle, and motility. Results: An analysis by the

SUBMITTER: Lu TJ 

PROVIDER: S-EPMC10158518 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature