Immune correlates of protection for SARS-CoV-2, Ebola and Nipah virus infection.

ABSTRACT: Correlates of protection (CoP) are biological parameters that predict a certain level of protection against an infectious disease. Well-established correlates of protection facilitate the development and licensing of vaccines by assessing protective efficacy without the need to expose clinical trial participants to the infectious agent against which the vaccine aims to protect. Despite the fact that viruses have many features in common, correlates of protection can vary considerably amongst the same virus family and even amongst a same virus depending on the infection phase that is under consideration. Moreover, the complex interplay between the various immune cell populations that interact during infection and the high degree of genetic variation of certain pathogens, renders the identifi

SUBMITTER: Escudero-Perez B 

PROVIDER: S-EPMC10158532 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature