The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset.

ABSTRACT: Evidence has accumulated that gut microbiota and its metabolites, in particular the short-chain fatty acid propionate, are significant contributors to the pathogenesis of a variety of diseases. However, little is known regarding its impact on pediatric bronchial asthma, one of the most common allergic diseases in childhood. This study aimed to elucidate whether, and if so how, intestinal propionate during lactation is involved in the development of bronchial asthma. We found that propionate intake through breast milk during the lactation period resulted in a significant reduction of airway inflammation in the offspring in a murine house dust mite-induced asthma model. Moreover, GPR41 was the propionate receptor involved in suppressing this asthmatic phenotype, likely through the upregulati

SUBMITTER: Ito T 

PROVIDER: S-EPMC10158560 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature