Left Frontal White Matter Links to Rhythm Processing Relevant to Speech Production in Apraxia of Speech.

ABSTRACT: Recent mechanistic models argue for a key role of rhythm processing in both speech production and speech perception. Patients with the non-fluent variant (NFV) of primary progressive aphasia (PPA) with apraxia of speech (AOS) represent a specific study population in which this link can be examined. Previously, we observed impaired rhythm processing in NFV with AOS. We hypothesized that a shared neurocomputational mechanism structures auditory input (sound and speech) and output (speech production) in time, a "temporal scaffolding" mechanism. Since considerable white matter damage is observed in NFV, we test here whether white matter changes are related to impaired rhythm processing. Forty-seven participants performed a psychoacoustic test battery: 12 patients with NFV and AOS, 11 patients

SUBMITTER: Bruffaerts R 

PROVIDER: S-EPMC10158569 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature