The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.

ABSTRACT: Snd1 is an evolutionarily conserved RNA-binding protein implicated in several regulatory processes in gene expression including activation of transcription, mRNA splicing, and microRNA decay. Here, we have investigated the outcome of Snd1 gene deletion in the mouse. The knockout mice are viable showing no gross abnormalities apart from decreased fertility, organ and body size, and decreased number of myeloid cells concomitant with decreased expression of granule protein genes. Deletion of Snd1 affected the expression of relatively small number of genes in spleen and liver. However, mRNA expression changes in the knockout mouse liver showed high similarity to expression profile in adaptation to hypoxia. MicroRNA expression in liver showed upregulation of the hypoxia-induced mi

SUBMITTER: Saarikettu J 

PROVIDER: S-EPMC10158624 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature