Novel immune cell infiltration-related biomarkers in atherosclerosis diagnosis.

ABSTRACT:

Background

Immune cell infiltration (ICI) has a close relationship with the progression of atherosclerosis (AS). Therefore, the current study was aimed to explore the role of genes related to ICI and to investigate potential mechanisms in AS.

Methods

Single-sample gene set enrichment analysis (ssGSEA) was applied to explore immune infiltration in AS and controls. Genes related to immune infitration were mined by weighted gene co-expression network analysis (WGCNA). The function of those genes were analyzed by enrichment analyses of the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). The interactions among those genes were visualized in the protein-protein interaction (PPI) network, followed by identification of hub genes through Cytoscape software. A r

SUBMITTER: Dong R 

PROVIDER: S-EPMC10158768 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature