Ameliorative effects of glycine on cobalt chloride-induced hepato-renal toxicity in rats.

ABSTRACT:

Background

The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride (CoCl₂ ). This study was designed to investigate the role of glycine in the mitigation of hepato-renal toxicities associated with CoCl₂ exposure.

Methods

Forty-two (42) male rats were grouped as Control; (CoCl₂ ; 300 ppm); CoCl₂  + Glycine (50 mg/kg); CoCl₂  + Glycine (100 mg/kg); Glycine (50 mg/kg); and Glycine (100 mg/kg). The markers of hepatic and renal damage, oxidative stress, the antioxidant defense system, histopathology, and immunohistochemical localization of neutrophil gelatinase associated lipocalin (NGAL) and renal p

SUBMITTER: Iji OT 

PROVIDER: S-EPMC10158950 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature