BpRNA-align: improved RNA secondary structure global alignment for comparing and clustering RNA structures.

ABSTRACT: Ribonucleic acid (RNA) is a polymeric molecule that is fundamental to biological processes, with structure being more highly conserved than primary sequence and often key to its function. Advances in RNA structure characterization have resulted in an increase in the number of accurate secondary structures. The task of uncovering common RNA structural motifs with a collective function through structural comparison, providing a level of similarity, remains challenging and could be used to improve RNA secondary structure databases and discover new RNA families. In this work, we present a novel secondary structure alignment method, bpRNA-align. bpRNA-align is a customized global structural alignment method, utilizing an inverted (gap extend costs more than gap open) and context-specific affine

SUBMITTER: Lasher B 

PROVIDER: S-EPMC10159002 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature