Short-term air pollution and temperature exposure and changes in the extracellular microRNA profile of Normative Aging Study (NAS) participants.

ABSTRACT:

Background

While the health effects of air pollution and temperature are widely studied, the molecular effects are poorly understood. Extracellular microRNAs (ex-miRNAs) have the potential to serve as diagnostic or prognostic biomarkers and/or to act as intercellular signaling molecules that mediate the effects of environmental exposures on health outcomes.

Methods

We examined the relationship between short-term exposure to air pollution and ambient temperature and the ex-miRNA profiles of participants in the Normative Aging Study (NAS) from 1999 to 2015. Our exposures were defined as same-day, two-day, three-day, one-week, two-week, and three-week moving averages of PM_2.5, NO₂, O₃, and temperature which were derived from high-resolution spat

SUBMITTER: Danesh Yazdi M 

PROVIDER: S-EPMC10159015 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature