Influence of surface characteristics of implant materials on MRSA biofilm formation and effects of antimicrobial treatment.

ABSTRACT:

Introduction

One of the main causes of treatment failure in bacterial prosthetic joint infections (PJI) is biofilm formation. The topography of the biofilm may be associated with susceptibility to antimicrobial treatment. The aims of this study were to assess differences in topography of biofilms on different implant materials and the correlation thereof with susceptibility to antimicrobial treatment.

Methods

Methicillin-resistant Staphylococcus aureus (MRSA) 7-day mature biofilms were generated on disks made from titanium alloys (Ti-6Al-7Nb and Ti-6Al-4V), synthetic polymer and orthopedic bone cement, commonly used in implant surgery. The surface topography of these implant materials and the biofilms cultured on them was assessed using atomic force microscopy. This p

SUBMITTER: van Dun SCJ 

PROVIDER: S-EPMC10159048 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature