Causal effects of opioids on postpartum depression: a bidirectional, two-sample Mendelian randomization study.

ABSTRACT:

Background

Postpartum depression is the most common psychiatric disorder in pregnant women during the postpartum period and requires early detection and treatment. Previous studies have found that opioids use affects depression and anxiety disorders. Although it has long been suspected that opioids may contribute to the development of postpartum depression, observational studies are susceptible to confounding factors and reverse causality, making it difficult to determine the direction of these associations.

Methods

To examine the causal associations between opioids and non-opioid analgesics with postpartum depression, we utilized large-scale genome-wide association study (GWAS) genetic pooled data from two major databases: opioids, salicylate analgesic, non-steroidal anti-i

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC10159056 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature