The effect of the genomic GC content bias of prokaryotic organisms on the secondary structures of their proteins.

ABSTRACT: One of the main characteristics of prokaryotic genomes is the ratio in which guanine-cytosine bases are used in their DNA sequences. This is known as the genomic GC content and varies widely, from values below 20% to values greater than 74%. It has been demonstrated that the genomic GC content varies in accordance with the phylogenetic distribution of organisms and influences the amino acid composition of their corresponding proteomes. This bias is particularly important for amino acids that are coded by GC content-rich codons such as alanine, glycine, and proline, as well as amino acids that are coded by AT-rich codons, such as lysine, asparagine, and isoleucine. In our study, we extend these results by considering the effect of the genomic GC content on the secondary structure of protein

SUBMITTER: Barcelo-Antemate D 

PROVIDER: S-EPMC10159118 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature