Determination of the effective dose of dexmedetomidine to achieve loss of consciousness during anesthesia induction.

ABSTRACT:

Background

Dexmedetomidine (DEX) is a sedative with greater preservation of cognitive function, reduced respiratory depression, and improved patient arousability. This study was designed to investigate the performance of DEX during anesthesia induction and to establish an effective DEX induction strategy, which could be valuable for multiple clinical conditions.

Methods

Patients undergoing abdominal surgery were involved in this dose-finding trial. Dixon's up-and-down sequential method was employed to determine the effective dose of DEX to achieve the state of "loss of consciousness", and an effective induction strategy was established with continuous infusion of DEX and remifentanil. The effects of DEX on hemodynamics, respiratory state, EEG, and anesthetic depth were monit

SUBMITTER: Mu B 

PROVIDER: S-EPMC10159180 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature