Polygenic risk scores for the prediction of common cancers in East Asians: A population-based prospective cohort study.

ABSTRACT:

Background

To evaluate the utility of polygenic risk scores (PRSs) in identifying high-risk individuals, different publicly available PRSs for breast (n=85), prostate (n=37), colorectal (n=22), and lung cancers (n=11) were examined in a prospective study of 21,694 Chinese adults.

Methods

We constructed PRS using weights curated in the online PGS Catalog. PRS performance was evaluated by distribution, discrimination, predictive ability, and calibration. Hazard ratios (HR) and corresponding confidence intervals (CI) of the common cancers after 20 years of follow-up were estimated using Cox proportional hazard models for different levels of PRS.

Results

A total of 495 breast, 308 prostate, 332 female-colorectal, 409 male-colorectal, 181 female-lung, and 381 male-lung inc

SUBMITTER: Ho PJ 

PROVIDER: S-EPMC10159619 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature