EpiTCR: a highly sensitive predictor for TCR-peptide binding.

ABSTRACT:

Motivation

Predicting the binding between T-cell receptor (TCR) and peptide presented by human leucocyte antigen molecule is a highly challenging task and a key bottleneck in the development of immunotherapy. Existing prediction tools, despite exhibiting good performance on the datasets they were built with, suffer from low true positive rates when used to predict epitopes capable of eliciting T-cell responses in patients. Therefore, an improved tool for TCR-peptide prediction built upon a large dataset combining existing publicly available data is still needed.

Results

We collected data from five public databases (IEDB, TBAdb, VDJdb, McPAS-TCR, and 10X) to form a dataset of >3 million TCR-peptide pairs, 3.27% of which were binding interactions. We proposed epiTCR, a Random

SUBMITTER: Pham MN 

PROVIDER: S-EPMC10159657 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature