The effect of plasma transfusion in an experimental two-hit animal model of transfusion-associated circulatory overload with heart failure.

ABSTRACT:

Background

Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-related morbidity and mortality. TACO follows a two-hit pathophysiology, where comorbidities like cardiac or renal failure act as the first hit followed by blood transfusion as a second hit. Observational studies suggest that plasma transfusion is more likely to cause TACO than other blood products. We conducted a randomized animal study to gather evidence that plasma transfusion can induce TACO.

Material and methods

As a first hit a large myocardial infarction was created in male Wistar rats. Then animals were randomized to receive 4 units of solvent/ detergent-treated pooled plasma (SDP), fresh frozen plasma (FFP), a colloid control (albumin 5%) or a crystalloid fluid control (R

SUBMITTER: Bulle EB 

PROVIDER: S-EPMC10159801 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature