Ontology highlight
ABSTRACT:
SUBMITTER: Aylan B
PROVIDER: S-EPMC10159855 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Aylan Beren B Bernard Elliott M EM Pellegrino Enrica E Botella Laure L Fearns Antony A Athanasiadi Natalia N Bussi Claudio C Santucci Pierre P Gutierrez Maximiliano G MG
Nature microbiology 20230323 5
Autophagy is a cellular innate-immune defence mechanism against intracellular microorganisms, including Mycobacterium tuberculosis (Mtb). How canonical and non-canonical autophagy function to control Mtb infection in phagosomes and the cytosol remains unresolved. Macrophages are the main host cell in humans for Mtb. Here we studied the contributions of canonical and non-canonical autophagy in the genetically tractable human induced pluripotent stem cell-derived macrophages (iPSDM), using a set o ...[more]