Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome.

ABSTRACT: Previous urinary tract infections (UTIs) can predispose one to future infections; however, the underlying mechanisms affecting recurrence are poorly understood. We previously found that UTIs in mice cause differential bladder epithelial (urothelial) remodelling, depending on disease outcome, that impacts susceptibility to recurrent UTI. Here we compared urothelial stem cell (USC) lines isolated from mice with a history of either resolved or chronic uropathogenic Escherichia coli (UPEC) infection, elucidating evidence of molecular imprinting that involved epigenetic changes, including differences in chromatin accessibility, DNA methylation and histone modification. Epigenetic marks in USCs from chronically infected mice enhanced caspase-1-mediated cell death upon UPEC infection, promoting b

SUBMITTER: Russell SK 

PROVIDER: S-EPMC10159856 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature