Stressful Life Events, Social Support, and Incident Breast Cancer by Estrogen Receptor Status.

ABSTRACT: Chronic stress affects immune function and hormonal signaling and has been hypothesized to be associated with breast cancer, although results from the few prior studies are mixed and have not examined potential differences by estrogen receptor (ER) status. Using the Women's Health Initiative study, we included 76,951 postmenopausal women followed for events for a median of 16.7 years to investigate the association between baseline self-reported stressful life events and incident breast cancer by ER status and whether the association was modified by social support. We generated Cox proportional hazards models adjusting for demographic, clinical, lifestyle/behavioral, and social factors to estimate HRs and 95% confidence intervals (95%CI). The mean age was 63 (SD, 7.3), and majority of parti

SUBMITTER: Lawrence WR 

PROVIDER: S-EPMC10159918 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature