Intranasal administration of Acinetobacter lwoffii in a murine model of asthma induces IL-6-mediated protection associated with cecal microbiota changes.

ABSTRACT:

Background

Early-life exposure to certain environmental bacteria including Acinetobacter lwoffii (AL) has been implicated in protection from chronic inflammatory diseases including asthma later in life. However, the underlying mechanisms at the immune-microbe interface remain largely unknown.

Methods

The effects of repeated intranasal AL exposure on local and systemic innate immune responses were investigated in wild-type and Il6^-/- , Il10^-/- , and Il17^-/- mice exposed to ovalbumin-induced allergic airway inflammation. Those investigations were expanded by microbiome analyses. To assess for AL-associated changes in gene expression, the picture arising from animal data was supplemented by in vitro experiments of macrophage and T-cell responses

SUBMITTER: Alashkar Alhamwe B 

PROVIDER: S-EPMC10160012 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature