Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue.

ABSTRACT: Obesity and type 2 diabetes are two closely related diseases representing a serious threat worldwide. An increase in metabolic rate through enhancement of non-shivering thermogenesis in adipose tissue may represent a potential therapeutic strategy. Nevertheless, a better understanding of thermogenesis transcriptional regulation is needed to allow the development of new effective treatments. Here, we aimed to characterize the specific transcriptomic response of white and brown adipose tissues after thermogenic induction. Using cold exposure to induce thermogenesis in mice, we identified mRNAs and miRNAs that were differentially expressed in several adipose depots. In addition, integration of transcriptomic data in regulatory networks of miRNAs and transcription factors allowed the identific

SUBMITTER: Rodo J 

PROVIDER: S-EPMC10160086 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature