Long-term risk associated with clonal hematopoiesis in patients with severe aortic valve stenosis undergoing TAVR.

ABSTRACT:

Background

Mutations in the clonal hematopoiesis of indeterminate potential (CHIP)-driver genes DNMT3A and TET2 have been previously shown to be associated with short-term prognosis in patients undergoing TAVR for aortic valve stenosis. We aimed to extend and characterize these findings on long-term outcome in a large cohort.

Methods

A total of 453 consecutive patients undergoing TAVR were included in an up to 4-year follow-up study. Next-generation sequencing was used to identify DNMT3A- and/or TET2-CHIP-driver mutations. Primary endpoint was all-cause mortality. Since CHIP-driver mutations appear to be closely related to DNA methylation, results were also assessed in patients who never smoked, a factor known to interfere with DNA methylation.

Results

DNMT3A-/TET2-CH

SUBMITTER: Mas-Peiro S 

PROVIDER: S-EPMC10160205 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature