The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data.

ABSTRACT: Numerous human proteins are classified as intrinsically disordered proteins (IDPs). Due to their physicochemical properties, high-resolution structural information about IDPs is generally lacking. On the other hand, IDPs are known to adopt local ordered structures upon interactions with e.g. other proteins or lipid membrane surfaces. While recent developments in protein structure prediction have been revolutionary, their impact on IDP research at high resolution remains limited. We took a specific example of two myelin-specific IDPs, the myelin basic protein (MBP) and the cytoplasmic domain of myelin protein zero (P0ct). Both of these IDPs are crucial for normal nervous system development and function, and while they are disordered in solution, upon membrane binding, they partially

SUBMITTER: Krokengen OC 

PROVIDER: S-EPMC10160357 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature