Quantitative optical coherence microscopy of neuron morphology in human entorhinal cortex.

ABSTRACT:

Introduction

The size and shape of neurons are important features indicating aging and the pathology of neurodegenerative diseases. Despite the significant advances of optical microscopy, quantitative analysis of the neuronal features in the human brain remains largely incomplete. Traditional histology on thin slices bears tremendous distortions in three-dimensional reconstruction, the magnitude of which are often greater than the structure of interest. Recently development of tissue clearing techniques enable the whole brain to be analyzed in small animals; however, the application in the human remains challenging.

Methods

In this study, we present a label-free quantitative optical coherence microscopy (OCM) technique to obtain the morphological parameters of neurons in hum

SUBMITTER: Wang H 

PROVIDER: S-EPMC10160389 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature