Cholera toxin B scaffolded, focused SIV V2 epitope elicits antibodies that influence the risk of SIV_mac251 acquisition in macaques.

ABSTRACT:

Introduction

An efficacious HIV vaccine will need to elicit a complex package of innate, humoral, and cellular immune responses. This complex package of responses to vaccine candidates has been studied and yielded important results, yet it has been a recurring challenge to determine the magnitude and protective effect of specific in vivo immune responses in isolation. We therefore designed a single, viral-spike-apical, epitope-focused V2 loop immunogen to reveal individual vaccine-elicited immune factors that contribute to protection against HIV/SIV.

Method

We generated a novel vaccine by incorporating the V2 loop B-cell epitope in the cholera toxin B (CTB) scaffold and compared two new immunization regimens to a historically protective 'standard' vaccine regimen (SVR

SUBMITTER: Rahman MA 

PROVIDER: S-EPMC10160393 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature