Oxygenation performance assessment of an artificial lung in different central anatomic configurations.

ABSTRACT:

Objectives

Aim of this work was to characterize possible central anatomical configurations in which a future artificial lung (AL) could be connected, in terms of oxygenation performance.

Methods

Pulmonary and systemic circulations were simulated using a numerical and an in vitro approach. The in vitro simulation was carried out in a mock loop in three phases: (1) normal lung, (2) pulmonary shunt (50% and 100%), and (3) oxygenator support in three anatomical configurations: right atrium-pulmonary artery (RA-PA), pulmonary artery-left atrium (PA-LA), and aorta-left atrium (Ao-LA). The numerical simulation was performed for the oxygenator support phase. The oxygen saturation (SO₂) of the arterial blood was plotted over time for two percentages of pulmonary shunt and

SUBMITTER: Hima F 

PROVIDER: S-EPMC10160396 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature