Labeled breath tests in patients with NASH: Octanoate oxidation relates best to measures of glucose metabolism.

ABSTRACT: In vivo methods to estimate human liver mitochondrial activity are lacking and this project's goal was to use a non-invasive breath test to quantify complete mitochondrial fat oxidation and determine how test results changed when liver disease state was altered over time. Patients with suspected non-alcoholic fatty liver disease (NAFLD; 9 men, 16 women, 47 ± 10 years, 113 ± 23 kg) underwent a diagnostic liver biopsy and liver tissue was histologically scored by a pathologist using the NAFLD activity score (0-8). To assess liver oxidation activity, a labeled medium chain fatty acid was consumed orally (23.4 mg ¹³C₄-octanoate) and breath samples collected over 135 min. Total CO₂ production rates were measured using breath ¹³CO₂ an

SUBMITTER: Mucinski JM 

PROVIDER: S-EPMC10160408 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature