Necroptosis-related lncRNAs: establishment of a gene module and distinction between the cold and hot tumors in glioma.

ABSTRACT:

Background

Gliomas are the most common primary tumors of the central nervous system and portend a poor prognosis. The efficacy of emerging and promising immunotherapies varies significantly among individuals. Distinction and transformation of cold and hot tumors may improve the antitumor efficacy of immunotherapy.

Methods and results

In this study, we constructed a necroptosis-related lncRNA module based on public databases. The association of this module with survival was assessed using the Cox regression, Kaplan-Meier survival analysis, and nomogram, external validation was also conducted in another public database. Furthermore, we performed gene set enrichment analysis (GSEA), immune checkpoint and tumor microenvironment analysis, and in vitro qRT-PCR validation. F

SUBMITTER: Cao K 

PROVIDER: S-EPMC10160458 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature