Full characterization of the three pathways of the complement system in patients with systemic lupus erythematosus.

ABSTRACT:

Background

To date a complete characterization of the components of the complement (C) pathways (CLassical, LEctin and ALternative) in patients with systemic lupus erythematosus (SLE) has not been performed. We aimed to assess the function of these three C cascades through functional assays and the measurement of individual C proteins. We then studied how they relate to clinical characteristics.

Methods

New generation functional assays of the three pathways of the C system were assessed in 284 patients with SLE. Linear regression analysis was performed to study the relationship between the activity, severity, and damage of the disease and C system.

Results

Lower values of the functional tests AL and LE were more frequent than those of the CL pathway. Clinical activity

SUBMITTER: Garcia-Gonzalez M 

PROVIDER: S-EPMC10160460 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature