Potential common molecular mechanisms between Sjogren syndrome and inclusion body myositis: a bioinformatic analysis and in vivo validation.

ABSTRACT:

Background

Inclusion body myositis (IBM) is a slowly progressive inflammatory myopathy that typically affects the quadriceps and finger flexors. Sjögren's syndrome (SS), an autoimmune disorder characterized by lymphocytic infiltration of exocrine glands has been reported to share common genetic and autoimmune pathways with IBM. However, the exact mechanism underlying their commonality remains unclear. In this study, we investigated the common pathological mechanisms involved in both SS and IBM using a bioinformatic approach.

Methods

IBM and SS gene expression profiles were obtained from the Gene Expression Omnibus (GEO). SS and IBM coexpression modules were identified using weighted gene coexpression network analysis (WGCNA), and differentially expressed gene (DEG) analysis

SUBMITTER: Zeng L 

PROVIDER: S-EPMC10160489 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature