Decellularized rat submandibular gland as an alternative scaffold for dental pulp regeneration.

ABSTRACT: Introduction: Decellularized extracellular matrix has been recognized as an optimal scaffold for dental pulp regeneration. However, the limited amount of native dental pulp tissue restricts its clinical applications. The submandibular gland shares some basic extracellular matrix components and characteristics with dental pulp. However, whether decellularized submandibular gland extracellular matrix (DSMG) can be used as an alternative scaffold for dental pulp regenerative medicine is unclear. Methods: Thus, we successfully decellularized the whole rat submandibular gland and human dental pulp, and then conducted in vitro and in vivo studies to compare the properties of these two scaffolds for dental pulp regeneration. Results: Our results showed that extr

SUBMITTER: Shi Y 

PROVIDER: S-EPMC10160494 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature