Growth and disease burden in children with hypophosphatasia.

ABSTRACT:

Objective

Hypophosphatasia, an inborn error of metabolism characterized by impaired bone mineralization, can affect growth. This study evaluated relationships between anthropometric parameters (height, weight, and body mass index) and clinical manifestations of hypophosphatasia in children.

Design

Data from children (aged <18 years) with hypophosphatasia were analyzed from the observational Global Hypophosphatasia Registry.

Methods

Anthropometric parameters were evaluated by age group (<2 years and ≥2 years) at assessment. The frequency of hypophosphatasia manifestations was compared between children with short stature (< percentile) and those with normal stature.

Results

This analysis included 215 children (54.4% girls). Short stature presented in 16.1% of chi

SUBMITTER: Hogler W 

PROVIDER: S-EPMC10160547 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature