MRNA-1273 boost after BNT162b2 vaccination generates comparable SARS-CoV-2-specific functional responses in naive and COVID-19-recovered individuals.

ABSTRACT:

Introduction

COVID-19 vaccines based on mRNA have represented a revolution in the biomedical research field. The initial two-dose vaccination schedule generates potent humoral and cellular responses, with a massive protective effect against severe COVID-19 and death. Months after this vaccination, levels of antibodies against SARS-CoV-2 waned, and this promoted the recommendation of a third vaccination dose.

Methods

We have performed an integral and longitudinal study of the immunological responses triggered by the booster mRNA-1273 vaccination, in a cohort of health workers previously vaccinated with two doses of the BNT162b2 vaccine at University Hospital La Paz located in Madrid, Spain. Circulating humoral responses and SARS-CoV-2-specific cellular reactions, after ex

SUBMITTER: Lozano-Rodriguez R 

PROVIDER: S-EPMC10160618 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature