Circulating metabolites and depression: a bidirectional Mendelian randomization.

ABSTRACT:

Background

Studies have shown an association between depression and circulating metabolites, but the causal relationship between them has not been elucidated. The purpose of this study was to elucidate the causal relationship between circulating metabolites and depression and to explore the role of circulating metabolites in depression.

Methods

In this study, the top single-nucleotide polymorphisms (SNPs) associated with circulating metabolites (n = 24,925) and depression (n = 322,580) were obtained based on the publicly available genome-wide association study using two-sample Mendelian randomization (MR). SNP estimates were summarized through inverse variance weighted, MR Egger, weighted median, MR pleiotropy residual sum and outlier, and "leave-one-out" metho

SUBMITTER: Dong Y 

PROVIDER: S-EPMC10160621 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature