Persistent T cell proliferation and MDSCs expansion precede incomplete CD4⁺ T cell recovery in people with acute HIV-1 infection with early ART.

ABSTRACT: HIV-1 infection causes T cell dysfunction that cannot be fully restored by anti-retroviral therapy (ART). Myeloid-derived suppressor cells (MDSCs) expand and suppress T cell function during viral infection. In this study, we evaluated the dynamics of phenotypes and function of T cells and MDSCs and the effects of their interaction on CD4⁺ T cell reconstitution in people with acute HIV-1 infection (PWAH) with early ART. Flow cytometry was used to detect the phenotypic dynamics and function of T cells and MDSCs at pre-ART, 4, 24, 48, and 96 weeks of ART. We observed that T cells were hyper-activated and hyper-proliferative in PWAH at pre-ART. Early ART normalized T cell activation but not their proliferation. T cell proliferation, enriched in PD-1⁺ T cells, was persiste

SUBMITTER: Li Z 

PROVIDER: S-EPMC10160758 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature