Moderate associations between BDNF Val66Met gene polymorphism, musical expertise, and mismatch negativity.

ABSTRACT: Auditory predictive processing relies on a complex interaction between environmental, neurophysiological, and genetic factors. In this view, the mismatch negativity (MMN) and intensive training on a musical instrument for several years have been used for studying environment-driven neural adaptations in audition. In addition, brain-derived neurotrophic factor (BDNF) has been shown crucial for both the neurogenesis and the later adaptation of the auditory system. The functional single-nucleotide polymorphism (SNP) Val66Met (rs6265) in the BDNF gene can affect BDNF protein levels, which are involved in neurobiological and neurophysiological processes such as neurogenesis and neuronal plasticity. In this study, we hypothesised that genetic variation within the BDNF gene w

SUBMITTER: Bonetti L 

PROVIDER: S-EPMC10160759 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature