Screening of Biomarkers Related to Myocardial Infarction Based on the Construction of a ceRNA Regulation Network.

ABSTRACT:

Background

This study aimed to identify the biomarkers related to myocardial infarction based on building lncRNA-miRNA-mRNA ceRNA regulation network.

Methods

The expression profile data were obtained from the Gene Expression Omnibus database. The differentially expressed RNAs (DElncRNAs, DEmiRNAs, and DEmRNAs) were analyzed using the limma package of R. In addition, the differential myocardial infarction-related genes were obtained and the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway on the differential myocardial infarction-related genes were analyzed. The co-expression network of lncRNA-mRNA was constructed, and the Kyoto Encyclopedia of Genes and Genomes pathway of such a co-expression network was analyzed. Moreover, the lncRNA-miRNA-mRNA ceRNA networ

SUBMITTER: Ma P 

PROVIDER: S-EPMC10160844 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature